Bifidobacterium Animalis Subsp. Lactis BB-12

 

Introduction

Bifidobacterium animalis subsp. lactis BB-12® — often just called BB-12® — is one of the most researched and trusted live cultures in the world. Originally developed by Danish scientists at Chr. Hansen in the early 1980s, BB-12® has been studied for decades and is now used globally in foods and supplements.

What makes this particular culture so well-known is the sheer amount of science behind it. BB-12® has featured in over 300 published studies, including more than 130 clinical trials involving people — and many of these were double-blind, placebo-controlled studies, the gold standard for scientific testing.

BB-12® belongs to a family of friendly bacteria naturally found in the human gut. It’s part of the Bifidobacterium genus, species animalis, subspecies lactis — with “BB-12®” being the specific strain name.

Scientists have spent years studying how BB-12® behaves in the body, and it stands out for several reasons:

  • Strong survival skills: BB-12® has been shown to survive the journey through the stomach and reach the intestines alive — even in challenging conditions such as exposure to acid and bile.
  • Excellent adhesion: It can attach to the gut’s natural mucous layer, helping it stay in place long enough to do its job.
  • Scientifically resilient: It’s a hardy strain that remains stable during manufacturing, storage, and shelf life, which makes it ideal for use in capsules and foods without the need for refrigeration.
  • Well-understood by science: BB-12® has been explored in a wide range of human studies looking at gut health, the balance of gut bacteria, digestive comfort, and general well-being across all ages.

 

Simply put, BB-12® combines decades of research with proven stability and reliability — qualities that make it one of the world’s most recognised and respected bacterial strains for everyday use.

 

Supporting Regularity & Comfort

 

Overview

A healthy digestive rhythm is something many of us take for granted — until it’s disrupted. Whether it’s changes in diet, travel, or simply everyday stress, the result can often be sluggish or irregular bowel movements.

That’s where Bifidobacterium animalis subsp. lactis BB-12® comes in. BB-12® is one of the world’s most researched live bacterial strains, known for its ability to support regularity and digestive comfort. Over the past 30 years, it has been featured in more than 130 human clinical studies, including several large double-blind, placebo-controlled trials — the gold standard of research

These studies show that BB-12® can help people maintain a smoother digestive rhythm and more comfortable bowel habits, particularly in those who experience slower or less frequent movements.

 

What the Research Shows

Researchers have explored BB-12® in a range of populations — from healthy adults to elderly residents — and the results are consistent and measurable:

  • In one of the largest studies, involving more than 1,200 adults with infrequent bowel movements, those who took BB-12® daily for four weeks were significantly more likely to experience an increase in their weekly bowel movements compared with the placebo group.
    • On average, participants taking BB-12® had one extra bowel movement per week.
    • The improvement was most notable in those with lower bowel frequency at the start.
  • In another study with elderly nursing-home residents, BB-12® increased the number of “normal” bowel days by around 35% compared with placebo. Twice as many participants in the BB-12® group achieved meaningful improvements in regularity.
  • Smaller studies with younger adults — especially women who tended to have slower bowel habits — found similar trends. After two weeks, those taking BB-12® reported noticeably more frequent and comfortable bowel movements.

 

Across all these trials, BB-12® was well tolerated and showed consistent benefits, particularly for individuals whose digestive rhythm was slower than average at baseline.

 

Why It Matters to You

Feeling regular and comfortable isn’t just about digestion — it affects energy, mood, and overall well-being. Occasional sluggishness can leave you feeling heavy or uncomfortable, and it’s something many people experience at some point.

The good news is that research shows BB-12® can help the gut find its natural rhythm again. By surviving the journey through the stomach and reaching the intestines alive, BB-12® helps maintain a healthy balance of bacteria — supporting smoother, more comfortable digestion day to day.

For those looking for a simple, natural way to support digestive regularity, BB-12® is one of the most trusted and well-studied bacterial strains in the world — backed by science, and built for everyday balance.

 

 

Supporting Gut Recovery After Antibiotics

 

Overview

Antibiotics are important medicines — but while they fight harmful bacteria, they can also disturb the delicate balance of friendly microbes that live in your gut. This is where Bifidobacterium animalis subsp. lactis BB-12® can help.

BB-12® is one of the world’s most researched live cultures, studied for how it helps the gut recover after antibiotic use. In several clinical studies, people who took BB-12® during or after a course of antibiotics experienced gentler digestive changes, shorter bouts of loose stools, and a faster return to normal gut balance compared to those who took a placebo.

It doesn’t replace the antibiotics themselves — but it’s been shown to help the gut bounce back more smoothly afterward.

 

What the Research Shows

Across multiple randomised, controlled human trials, scientists have explored how BB-12® behaves during antibiotic use:

  • In one large double-blind study of over 340 adults taking antibiotics for a week, participants who consumed a blend containing BB-12® had:
    • Shorter duration of diarrhoea — 2 days on average vs 4 days in the placebo group.
    • Less severe symptoms — only around 1 in 3 in the BB-12® group reported watery stools, compared to almost all participants in the placebo group.
    • A modest reduction in the number of people who developed diarrhoea overall (10.8% vs 15.6%).
  • In a more recent trial of 62 healthy adults, researchers looked beyond symptoms to what was happening inside the gut. After a 7-day antibiotic course, those who took BB-12® recovered their natural gut balance much faster:
    • Key gut compounds (called short-chain fatty acids) returned to normal within 30 days in the BB-12® group, but remained below normal in the control group.
    • The diversity of gut bacteria — a marker of gut health — stayed more stable in those taking BB-12®.
  • In smaller studies with children, BB-12® used in yogurt or milk was associated with fewer episodes of loose stools and quicker recovery after antibiotics.

 

Altogether, these studies consistently show that BB-12® can help support the gut’s natural balance and recovery process when it’s been disrupted by antibiotics.

 

Why It Matters to You

Anyone who’s taken antibiotics knows that they can sometimes leave the digestive system feeling “off.” That’s because antibiotics don’t just target the harmful bacteria — they can also affect the beneficial ones that help keep things running smoothly.

The research on BB-12® shows that it helps the gut regain its balance more quickly, lessens discomfort, and reduces how long disturbances last. In other words, it helps your system find its rhythm again naturally.

For those who like to look after their digestive health — especially during times when the gut might be under extra stress — BB-12® is one of the best-studied and most trusted bacterial strains available today.

It’s a simple, natural way to support your gut’s resilience when it needs it most.

 

 

Supporting Immune and Respiratory Function

 

Overview

Your immune system and your gut are deeply connected — around 70% of your body’s immune cells are located in the intestinal lining. It’s one of the body’s busiest communication hubs, constantly learning, adapting, and responding to what you eat and what you’re exposed to.

Bifidobacterium animalis subsp. lactis BB-12® is one of the world’s most researched live bacterial strains for supporting this connection. Scientists have explored how it interacts with the immune system — from helping the body respond to vaccines, to supporting balance during seasonal challenges and everyday immune stress.

Across numerous clinical trials in adults, children, and infants, BB-12® has been shown to help the immune system stay resilient and responsive, while also helping people feel healthier during times when the body is under pressure.

 

What the Research Shows

Stronger response to vaccination

In a large double-blind, placebo-controlled study of over 200 healthy adults, those who took BB-12® daily for six weeks (two before and four after an influenza vaccination) showed a stronger antibody response to the vaccine than those who took a placebo. Levels of key immune markers — including IgG and IgA, which help the body recognise and respond to challenges — were all higher in the BB-12® group.

These results suggest that BB-12® helps the immune system respond more efficiently, without overstimulating it.

 

Fewer respiratory infections in infants

In a randomised, controlled trial involving more than 100 infants, researchers found that babies who received BB-12® daily through a specially designed pacifier tablet were significantly less likely to develop respiratory infections during their first months of life.

About 65% of the infants who took BB-12® experienced an infection, compared with 94% of those given a placebo — a 31% reduction in risk.

While this study focused on early life, it provides important insight into how BB-12® interacts naturally with the immune system from a young age.

 

Shorter, milder colds in adults (BB-12® + LGG®)

In another double-blind, placebo-controlled study, over 230 college students took a daily combination of BB-12® and LGG® — the same two strains offered in the BetterGuts range — for twelve weeks during the winter months.

 

Students taking the two-strain blend reported:

  • Shorter colds — around 2 days less on average
  • Milder symptoms — about 34% lower severity
  • Fewer missed study days, compared to those taking a placebo

 

This research highlights how BB-12® and LGG® can complement each other: while BB-12® supports immune balance and gut function, LGG® is renowned for its ability to help the body maintain resilience during everyday challenges. Together, they make a powerful and well-researched combination.

 

Increased protective immune markers

Smaller studies in adults have found that taking BB-12® daily for just a few weeks can increase natural immune markers in the gut, including secretory IgA — a key line of defence for the intestinal and respiratory surfaces. These findings provide a biological explanation for the results seen in larger studies.

 

Why It Matters to You

Your immune system is constantly active — but it also depends on balance. When that balance is disrupted by stress, travel, diet, or the changing seasons, your body’s defences can feel sluggish.

The research on BB-12® shows that it can help the immune system respond more efficiently, recover more quickly, and maintain its natural rhythm of protection. It’s not about overstimulation — it’s about helping your body stay ready, steady, and resilient.

Whether it’s supporting the body’s response to seasonal changes, helping maintain comfort during everyday immune stress, or pairing with BetterGuts LGG® for broader coverage, BB-12® is one of the most trusted and scientifically backed bacterial strains for year-round wellbeing.

 

Supporting Gut Balance During H. pylori Therapy

Overview

 

Helicobacter pylori — often simply called H. pylori — is a common type of bacteria that can live in the stomach. For many people it causes no problems, but for others, it can contribute to digestive discomfort or require treatment with antibiotics. Unfortunately, those antibiotic courses can be tough on the gut, often leading to side effects like bloating or loose stools.

That’s where Bifidobacterium animalis subsp. lactis BB-12® has been studied most extensively. Researchers have explored how this well-known live culture, often combined with Lactobacillus acidophilus LA-5®, can help to support balance and comfort during H. pylori treatment and beyond.

Across seven human clinical studies, including several large, randomised double-blind placebo-controlled trials involving hundreds of participants, BB-12® has repeatedly been shown to:

  • Support higher H. pylori eradication success when used alongside standard medical treatment.
  • Help reduce common digestive side effects associated with antibiotics.
  • Promote faster restoration of natural gut bacteria after therapy.

 

What the Research Shows

Improved treatment success and gut recovery

In one double-blind, placebo-controlled study of 160 adults, those who received standard H. pylori therapy along with a yogurt containing BB-12® and LA-5® achieved a 91% treatment success rate, compared to 78% in the group who received medication alone. Researchers also found that only the BB-12® group successfully restored healthy Bifidobacterium levels in the gut afterwards.

A second high-quality RCT involving 138 adults who had not responded to initial antibiotic therapy found similar results. After taking BB-12® and LA-5® daily for four weeks before retrying treatment, eradication rates rose from 71% to 85%, and patients reported fewer digestive side effects.

These studies are particularly meaningful because they are randomised, double-blind, placebo-controlled — the most reliable form of clinical testing — and included hundreds of adults, giving strong confidence in the results.

 

Helping calm the stomach naturally

In another controlled trial involving 70 adults who carried H. pylori but weren’t taking antibiotics, a yogurt containing BB-12® and LA-5® was consumed twice daily for six weeks. The results showed a highly significant reduction in H. pylori activity (P < 0.0001), meaning the bacteria became much less active. Laboratory work from the same study also revealed that BB-12® could directly inhibit H. pylori, highlighting its natural interaction with the stomach environment.

 

Easier tolerance of antibiotic therapy

A separate double-blind, placebo-controlled study of 88 adults receiving H. pylori treatment found that those who took a fermented milk drink containing BB-12® and LA-5® experienced shorter episodes of antibiotic-associated diarrhoea — just 4 days on average, compared with 10 days for those taking a control product.

All participants saw some reduction in H. pylori activity, but only the BB-12® group maintained healthy gut balance and comfort throughout treatment.

 

Consistent results across large populations

When data from multiple studies were combined in a meta-analysis including more than 300 adults undergoing H. pylori eradication therapy, researchers found that using BB-12® (with LA-5®) alongside medication more than doubled the odds of successful eradication (odds ratio 2.42; 95% CI 1.34–4.34) and cut the risk of side effects by around 70%.

Even when BB-12® wasn’t used as part of antibiotic therapy, studies consistently showed that it could help calm the stomach, support a healthy balance of gut flora, and reduce digestive discomfort.

 

Why It Matters to You

If you’ve ever been prescribed antibiotics for H. pylori, you’ll know how harsh those treatments can be on the digestive system. The research on BB-12® provides a clear picture: adding a high-quality live culture can make that experience gentler, smoother, and more effective.

In multiple large clinical studies — the same kind doctors rely on to guide evidence-based medicine — people who took BB-12® alongside their prescribed treatment not only had better eradication success but also fewer side effects and quicker recovery of their gut’s natural balance.

For anyone who values digestive comfort during or after antibiotic use, BB-12® stands out as one of the most studied and trusted bacterial strains in the world — shown in gold-standard research to help support your gut when it needs it most.

 

Supporting Comfort and Growth in Early Life

 

Overvie

The first months of life are a time of rapid change — not only for a baby’s body, but also for their developing gut. This delicate environment plays a crucial role in digestion, comfort, and immune development. For some infants, this adjustment period can bring challenges such as colic, irregular digestion, or slower weight gain — all of which can place stress on both baby and parent.

That’s where Bifidobacterium animalis subsp. lactis BB-12® has been most widely studied in young populations. Over the past two decades, scientists have conducted several high-quality human studies — many of them double-blind, placebo-controlled clinical trials, the gold standard of medical research — exploring how BB-12® may help infants establish balance and comfort in the earliest stages of life.

Across these studies, BB-12® has shown strong, consistent benefits: helping to reduce the symptoms of infant colic, supporting steady growth in preterm infants, and promoting a healthier gut and immune environment right from the start.

 

What the Research Shows

Calmer, more comfortable babies

In a double-blind, placebo-controlled study of 80 infants with colic, researchers found that babies who received BB-12® drops once a day for four weeks cried and fussed around 65% less, compared to an 18% reduction in the placebo group.

In practical terms, that meant daily crying time dropped from over three hours to just about one hour on average — a change most parents would call life-changing.

What’s more, the babies taking BB-12® showed signs of better gut comfort at a biological level: higher protective immune markers (sIgA) and lower calprotectin, an indicator of gut inflammation.

A follow-up study confirmed these results, showing that the improvements lasted even after supplementation stopped, and that babies continued to show signs of balanced gut function.

 

Supporting growth and gut balance in preterm infants

In another double-blind, placebo-controlled clinical trial of 69 preterm infants, BB-12® was added daily to expressed breast milk for three weeks. The babies receiving BB-12® gained weight faster — about 30% more daily growth than the placebo group — and developed a more balanced gut environment, with higher levels of beneficial bacteria and lower signs of inflammation.

Follow-up work in the same group showed that these effects persisted for weeks after supplementation ended, with the babies’ microbiota continuing to mature and stabilise more quickly than those who didn’t receive BB-12®.

 

These results were achieved safely, without any adverse effects reported — an important factor in such a sensitive population.

 

Consistency and scientific strength

Across these four gold-standard clinical trials, involving more than 300 infants, the findings are remarkably consistent:

  • Babies receiving BB-12® cried less, grew more, and showed better immune balance.
  • All studies were randomised, double-blind, placebo-controlled — meaning neither parents nor researchers knew which infants received BB-12® until after the results were analysed.
  • The results were not just statistically significant, but clinically meaningful — reflecting real improvements in comfort, feeding, and wellbeing.

 

Why It Matters to You

Early life sets the stage for a child’s long-term health. When an infant’s digestion is calm and balanced, everything from feeding to sleep tends to go more smoothly — and the benefits ripple outward for the whole family.

The research on BB-12® shows that it can play a gentle, natural role in helping to establish that balance. By supporting healthy bacteria in the gut, BB-12® helps create the conditions for comfort, steady growth, and a resilient immune system in the earliest months of life.

For parents seeking something backed by rigorous science, BB-12® is one of the most researched bacterial strains ever studied in infants — tested in multiple double-blind, placebo-controlled trials, and consistently shown to support comfort, growth, and gut balance from the very beginning.

Supporting a Healthy Start for the Mouth

 

Overview

Your mouth is home to one of the body’s most complex communities of bacteria — even from the very first months of life. In early childhood, these bacteria begin to shape the balance between a healthy oral environment and the species linked with tooth decay.

Although most research into Bifidobacterium animalis subsp. lactis BB-12® has focused on digestion and immunity, scientists have recently started exploring its potential role in the mouth as well. The evidence here is still new and developing, but the first human studies are encouraging, showing that BB-12® may help influence the early oral microbiome in a positive way.

 

What the Research Shows

In a double-blind, placebo-controlled study involving more than 100 healthy infants, researchers gave babies a pacifier containing BB-12® (1 billion CFU daily) or a placebo for one year. When the children were later tested, those who had received BB-12® were almost half as likely to carry mutans streptococci — a type of bacteria closely associated with the formation of dental caries (tooth decay).

Specifically, only 16 percent of babies in the BB-12® group carried these bacteria compared with 29 percent in the placebo group — a statistically significant difference that suggests BB-12® helped shape a more balanced, less cavity-prone oral environment.

A follow-up study of the same children several years later found that, while overall tooth-decay rates were similar between groups, the original BB-12® group still had lower levels of the same cavity-linked bacteria. It’s also worth noting that by this stage the children had not been taking BB-12® for several years and were otherwise living very similar lifestyles — a factor that likely influenced the long-term results.

Taken together, these early studies indicate that BB-12® may help reduce colonisation by cavity-related bacteria during infancy, though further research is needed to confirm how this might translate into longer-term oral-health benefits.

 

Why It Matters to Yo

A healthy oral microbiome begins early. Reducing the presence of bacteria such as mutans streptococci in the first years of life can set the stage for a more balanced mouth and may support the natural defences that help protect developing teeth.

While research into BB-12® and oral health is still in its early stages, the findings so far are promising. They suggest that the same well-studied bacterial strain known for supporting gut balance and immune function may also play a gentle, beneficial role in helping the mouth maintain harmony from the very beginning.

As more studies emerge, BB-12® continues to show itself as one of the most versatile and well-researched bacterial strains — helping scientists better understand how the microbiome connects our gut, our immune system, and even our smiles.

Bringing It All Together: The Story of BB-12®

 

Over the past three decades, Bifidobacterium animalis subsp. lactis BB-12® has become one of the world’s most studied and trusted bacterial strains. Its story is one of consistency, care, and scientific depth — explored in dozens of human clinical trials involving thousands of people across every stage of life, from newborns to older adults.

 

What stands out most about BB-12® is the strength and reliability of the research behind it. Many of its studies have been randomised, double-blind, placebo-controlled clinical trials — the gold standard of scientific testing — and together they paint a remarkably coherent picture of a bacterial strain that helps support balance and wellbeing in several important ways.

 

In digestive health, BB-12® has been shown to help maintain a natural rhythm and comfort in the gut. In large-scale human trials, adults taking BB-12® experienced more regular and comfortable bowel movements, reflecting its gentle influence on the body’s natural digestive processes.

 

When used alongside antibiotic therapy, BB-12® has also been shown to help the gut recover more smoothly. People taking BB-12® during or after a course of antibiotics experienced shorter periods of digestive discomfort and a faster return to their usual balance, supporting the body’s ability to restore itself naturally.

 

Its benefits extend beyond digestion, too. In studies of immune and respiratory function, BB-12® has been shown to strengthen the body’s natural defences. Adults who took BB-12® demonstrated stronger antibody responses after vaccination; infants given BB-12® were less likely to experience respiratory infections; and in university students, a combination of BB-12® and Lacticaseibacillus rhamnosus GG (LGG®) led to milder, shorter-lasting colds and fewer missed days.

 

Clinical research has also explored BB-12® in people undergoing treatment for Helicobacter pylori, a common stomach bacterium. When used alongside standard medical therapy, BB-12® has been shown to improve treatment success, reduce the digestive side effects often caused by antibiotics, and help restore healthy gut bacteria more quickly once therapy ends.

 

Perhaps most remarkably, BB-12® has also been studied in the earliest stages of life. In infants with colic, it has been shown to reduce daily crying time by around two-thirds, bringing significant relief for both babies and parents. In preterm infants, BB-12® supplementation has been linked to faster growth, stronger immune readiness, and a healthier gut environment — all achieved safely under careful clinical conditions.

 

And while research into oral health is still in its early stages, initial studies suggest that BB-12® may also help reduce colonisation by cavity-associated bacteria in infants, pointing to a potentially broader role in supporting a balanced oral microbiome in the future.

 

Taken together, these findings make BB-12® one of the most comprehensively researched bacterial strains in the world. Its effects have been tested across multiple systems of the body — the gut, the immune system, and even the mouth — and the results consistently show a pattern of balance, comfort, and resilience.

 

BB-12® is not a quick fix or a trend. It is the product of decades of careful scientific study, built on rigorous evidence and a deep understanding of how our internal ecosystems contribute to our wellbeing. From supporting digestion and recovery to promoting comfort and growth in early life, BB-12® represents a simple, natural way to help the body stay in harmony — a small strain with an impressive story, and a reassuring place in the science of everyday health.

 

 

Disclaimer

 

All information provided on this page is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. The studies referenced in this article were conducted independently and are not affiliated with, conducted by, or conducted for, BetterGuts or Strain Supplements Ltd.

Always consult a qualified healthcare professional before starting any new supplement.

 

 

References

Gastrointestinal and Bowel Function

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Antibiotic-Associated Diarrhoea

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Immune and Respiratory Function

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Helicobacter pylori Management

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Infant Colic and Early-Life Support

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Oral Microbiome

  1. Taipale, T., Pienihäkkinen, K., Isolauri, E., Jokela, J., Söderling, E. & Salminen, S. (2012). Bifidobacterium animalis subsp. lactis BB-12® administration in early childhood reduces mutans streptococci colonisation: a randomized, double-blind, placebo-controlled study. Caries Research, 46(5), 455–460. https://doi.org/10.1159/000339347
  2. Taipale, T., Pienihäkkinen, K., Isolauri, E., Jokela, J., Söderling, E. & Salminen, S. (2013). Bifidobacterium animalis subsp. lactis BB-12® and the risk of early childhood caries: four-year follow-up of a randomized controlled trial. Caries Research, 47(5), 364–372. https://doi.org/10.1159/000350641